TRAP-2

Studie TRAP-2
Titel studie The efficacy of the addition of TRAstuzumab and Pertuzumab to neoadjuvant chemoradiation: a randomized multi-center study in resectable HER2 overexpressing esophageal adenocarcinoma.
Aandachtsgebied Gastro Enterologie
Doel In deze studie wordt het effect onderzocht van toevoeging van trastuzumab en pertuzumab aan de standaardbehandeling van slokdarmkanker met chemoradiatie gevolgd door een operatie.
Juni 2022
Locatie Deventer/Apeldoorn
Patiëntinformatie Inclusie vind plaats in het Deventer Ziekenhuis/ Gelre Ziekenhuis.
TRAP-2

Helical 4D-CT pitch management for the Brilliance CT Big Bore in clinical practice

Titel Helical 4D-CT pitch management for the Brilliance CT Big Bore in clinical practice
Auteurs G. Hilgers, T. Nuver and A. Minken
Aandachtsgebied Longen,  Gastro-enterologie
Samenvatting In external beam radiotherapy treatment planning for patients with thoracic malignancies, respiratory-correlated CT (4D CT) is used to obtain high quality studies in the presence of respiratory motion. When helical 4D CT scans are acquired with a Brilliance CT Big Bore, the pitch must meet two conditions. It must be low enough to avoid motion artifacts, and high enough to cover the entire scan length within 120 s to prevent overheating of the X-ray tube. We developed a nomogram that can be used to obtain a suitable pitch satisfying both requirements. We also assessed the effects on the image quality of a pitch that exceeds the maximum pitch, and of a field of view (FOV) reduction. It was shown that, for AVG and MIP reconstructions, the manufacturer’s maximum pitch equation yields an underestimation due to its FOV term.
Datum 2015
Locatie J Appl Clin Med Phys.  2015 in press 
Link PubMed Abstract

Rectal dose constraints for salvage iodine-125 prostate brachytherapy.

Titel Rectal dose constraints for salvage iodine-125 prostate brachytherapy.
Auteurs Peters M, Hoekstra CJ, van der Voort van Zyp JR, Westendorp H, van de Pol SM, Moerland MA, Maenhout M, Kattevilder R, van Vulpen M.
Aandachtsgebied Brachytherapy, Urologie, Gastro-enterologie
Samenvatting Organ-confined prostate cancer recurrences after primary radiotherapy can be treated with salvage iodine-125 brachytherapy. Options include total salvage (TS) or focal salvage (FS). TS often leads to severe late gastrointestinal (GI) toxicity. Differences in rectal dosimetry between TS and FS are presented and dose constraints proposed to reduce late severe GI toxicity (>90 days).
Datum januari 2015
Locatie Brachytherapy. 2016 Jan-Feb;15(1):85-93. doi: 10.1016/j.brachy.2015.10.004. Epub 2015 Nov 21.
Link PubMed Abstract

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